Glucosamine HCl (Hydrochloride)

Glucosamine HCl (Hydrochloride) is a tier 2 form of Glucosamine, used in 379 on-market products .

Why this tier: The largest single trial (GAIT, NIH-funded, n>1,500) used glucosamine HCl and found NO significant overall benefit vs placebo -- weaker/more mixed evidence than sulfate for whole-population efficacy, though one Chinese multi-center RCT found HCl and sulfate equally effective head-to-head; the gap is debated, not settled.

Source: Clegg DO et al. 2006, NEJM 354(8):795-808 (GAIT); Qiu GX et al. 2005, Zhonghua Yi Xue Za Zhi 85(43):3067-3070

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