Manganese Amino Acid Chelate vs. Manganese Sulfate
Among 4,675 on-market manganese products with an identifiable primary form, 28% use Manganese Amino Acid Chelate (1,309 products) and 27.9% use Manganese Sulfate (1,306).
| Manganese Amino Acid Chelate | Manganese Sulfate | |
|---|---|---|
| Quality tier | Unrated | Tier 2 |
| Manganese by weight | 27.0% | 32.5% |
| Share of market | 28% | 27.9% |
| On-market products | 1,309 | 1,306 |
| Median declared dose | 2,000 elemental mcg middle half: 1,000–4,800 | 2,000 elemental mcg middle half: 2,000–2,500 |
| Most common brands | NOW, XYMOGEN, Bluebonnet | GNC Mega Men, GNC Women's Ultra Mega, 21st Century |
Doses are declared per serving in elemental mcg. “By weight” is the share of the ingredient that is the nutrient itself (e.g. elemental magnesium in a magnesium salt).
Why Manganese Amino Acid Chelate is unrated
Animal (poultry) data suggest higher relative bioavailability than MnSO4, but NIH ODS confirms no human data exist -- not willing to assert a human-relevant tier on animal-only evidence.
Source: uncertain -- needs review (animal/poultry evidence only)
Why Manganese Sulfate is tier 2
NIH ODS states no human comparative bioavailability data exist across manganese forms; treated as "acceptable by convention" (soluble reference salt used in mostly-animal research), not evidence-ranked.
Source: https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/