Methylsulfonylmethane (MSM)
Of 1,747 on-market methylsulfonylmethane (msm) products in the January 2026 DSLD dump, the median declared dose is 500 mg, and 92.6% list unspecified/undisclosed form as the primary form.
Form share
Of 1,746 products with an identifiable primary form, here is the share held by each form of Methylsulfonylmethane (MSM) on the market today.
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| Form | Quality tier | n | Share |
|---|---|---|---|
| unspecified/undisclosed form | Unrated | 1,616 | 92.6% |
| OptiMSM (branded MSM) | Unrated | 130 | 7.4% |
Form share over time
Entry-year breakdown of the top forms, 2012–2025.
Dose distribution
Deciles of declared dose per serving (mg), among 1,379 products with a disclosed amount.
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- 64.2% of products fall below the fairy-dust threshold (675 mg, 20% of the studied low dose).
- 20.3% of products don't disclose an amount because Methylsulfonylmethane (MSM) is declared inside a proprietary blend.
Where does your dose rank?
Enter a per-serving dose (mg) to see exactly how it compares to the 1,379 on-market methylsulfonylmethane (msm) products with a disclosed amount. The chart above groups doses into deciles; this looks up the exact percentile for one number.
By dosage form
By target group
Top brands
Search interest over time
How often people search for methylsulfonylmethane (msm) on Google, US only, the last 5 years. This is public interest, not DSLD label data — a spike here doesn't necessarily line up with anything on this page, and Google's own index (100 = that term's peak popularity in the chosen window) is relative, not an absolute search-volume count.
Or see this search directly on trends.google.com.
Forms explained
Label discloses only MSM/methylsulfonylmethane (a single small molecule with no salt or isomer forms).
Branded raw material of the same molecule; no head-to-head human comparison against generic MSM was verified, so it is not ranked.
Reference values
- RDA (adult): not established — Organosulfur compound, not an essential nutrient; no DRI exists.
- Tolerable Upper Intake Level (adult): not established — Not established. A pilot RCT dosing 6 g/day (3 g twice daily) for 12 weeks (n=50) reported no major adverse events (PMID 16309928); this is one small short trial, not a UL.
- Studied clinical dose range: 3375–6000 mg
- Debbi EM et al. 2011, BMC Complement Altern Med 11:50, PMID 21708034 -- double-blind RCT, n=49 knee OA, MSM 1.125 g three times daily (3.375 g/day) x12 weeks; significant improvement in WOMAC physical function and total score vs placebo (P=0.04, 0.03) but not WOMAC pain/stiffness; authors call the gains small. Kim LS et al. 2006, Osteoarthritis Cartilage 14(3):286-294, PMID 16309928 -- pilot double-blind RCT, n=50 knee OA, MSM 3 g twice daily (6 g/day) x12 weeks; significantly lower WOMAC pain and physical-function impairment vs placebo.
- Note: Both verified trials are small and used multi-gram doses; typical retail doses (500-1500 mg) are below the studied range, so the fairy-dust flag will fire often -- that reflects the evidence, not a data error. OptiMSM is a branded distilled MSM (same molecule). Rows in grams are normalized to mg. "Chondroitin/MSM Complex" and "Sulfur/MSM" rows are NOT aliases (complex weight / sulfur source).