Berberine HCl (Hydrochloride)
Berberine HCl (Hydrochloride) is a tier 1 form of Berberine, used in 423 on-market products .
423
on-market products
tier 1
quality tier
n/a
elemental fraction
Why this tier: The form used in the overwhelming majority of clinical trials, including the metformin-comparison trial and most diabetes/lipid meta-analysis literature -- despite reported low oral bioavailability, it has the deepest outcome-level human evidence.
Source: Yin J et al. 2008, Metabolism 57(5):712-7, PMID 18442638; Zhang Y et al. 2008, J Clin Endocrinol Metab 93(7):2559-65, PMID 18397984; Xiang ZD et al. 2024, Phytomedicine 126:155444, PMID 38367423 (review: low oral bioavailability)