Supplement Label Index

Chromium Polynicotinate vs. Chromium Chloride

Among 4,926 on-market chromium products with an identifiable primary form, 24.6% use Chromium Polynicotinate (1,211 products) and 14.2% use Chromium Chloride (700).

Chromium PolynicotinateChromium Chloride
Quality tierTier 2Tier 3
Chromium by weight19.5%
Share of market24.6%14.2%
On-market products1,211700
Median declared dose120 elemental mcg
middle half: 50–200
100 elemental mcg
middle half: 35–120
Most common brandsDouglas Laboratories, Pure Encapsulations, Wonder LaboratoriesNew Chapter, GNC Mega Men, Nature Made

Doses are declared per serving in elemental mcg. “By weight” is the share of the ingredient that is the nutrient itself (e.g. elemental magnesium in a magnesium salt).

Why Chromium Polynicotinate is tier 2

Nicotinate-based forms absorbed better than chloride but worse than picolinate in the same comparative study.

Source: DiSilvestro RA, Dy E. 2007, PMID 17499152 (form-class evidence, not this specific branded complex)

Why Chromium Chloride is tier 3

Produced significantly lower 24h urinary Cr than picolinate in the same crossover study -- cheapest/most common multivitamin form but weakest absorption signal.

Source: DiSilvestro RA, Dy E. 2007, PMID 17499152

Tiers summarize published comparative bioavailability or outcome evidence for each form (see methodology). This page describes the market; it is not a recommendation to take either form. Talk to a clinician about what's right for you.

Other chromium comparisons